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Spontaneous Gene Mutations Cause Autism

There's now the theory that gene mutations are causing autism. A paper was published in the Journal Cell where research reveals that an enzyme named UBE3A could be turned off when a phosphate molecule is tacked onto UBE3A. In neurons and during brain development, this switch may be turned either off or on, which leads to rather tight regulation of UBE3A. A research team discovered that an autism-connected mutation harms this regulatory switch. As a result of the destruction of the switch, that causes an enzyme's inability to be turned off, UBE3A gets hyperactive and fuels abnormal brain development and autism.

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